|
rs11122324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention.
|
30976040 |
2019 |
|
rs2793091
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found two SNPs (rs11122324 and rs2793091) of DISC1 may be specifically associated with multiplex schizophrenia patients with deficient sustained attention.
|
30976040 |
2019 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Although the conformation of DISC1 partial peptide with the schizophrenia-related mutation L607F in human or the corresponding L604F in mouse was essentially indistinguishable from the wild type (WT) as long as monitored by fluorescence, circular dichroism, ultracentrifugation, dynamic light scattering and nuclear magnetic resonance, the atomic force microscopy was able to detect their morphological distinctions.
|
30561706 |
2019 |
|
rs746969672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although the conformation of DISC1 partial peptide with the schizophrenia-related mutation L607F in human or the corresponding L604F in mouse was essentially indistinguishable from the wild type (WT) as long as monitored by fluorescence, circular dichroism, ultracentrifugation, dynamic light scattering and nuclear magnetic resonance, the atomic force microscopy was able to detect their morphological distinctions.
|
30561706 |
2019 |
|
rs6675281
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our data revealed that the three SNPs are significantly associated with schizophrenia (rs2255349 C>T: confidence interval (CI), 2.115 to 3.268; P = 0.0000 OR: 2.629; rs2738864 C>T: CI, 1.538 to 2.339; P = 0.0000 OR: 1.897; rs6675281 C>T: CI, 2.788 to 4.662; P = 0.0009241 OR: 3.605).
|
30324622 |
2018 |
|
rs2255340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The purpose of this study was to investigate the association of three single-nucleotide polymorphisms (SNPs; rs6675281, rs2255340, and rs2738864) with schizophrenia disorder.
|
30324622 |
2018 |
|
rs2738864
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our data revealed that the three SNPs are significantly associated with schizophrenia (rs2255349 C>T: confidence interval (CI), 2.115 to 3.268; P = 0.0000 OR: 2.629; rs2738864 C>T: CI, 1.538 to 2.339; P = 0.0000 OR: 1.897; rs6675281 C>T: CI, 2.788 to 4.662; P = 0.0009241 OR: 3.605).
|
30324622 |
2018 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.
|
30286368 |
2018 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found that SNP rs821597 is significantly associated with schizophrenia risk in terms of both allelic and genotypic distribution, while SNP rs821616 is associated with schizophrenia in terms of genotypic distribution, especially in cases above 40 years old.
|
30286368 |
2018 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This meta-analysis indicated that rs3737597 of DISC1 was significantly associated with schizophrenia in Europeans, and it can be suggested as an ethnic-specific risk genetic factor.
|
30252773 |
2018 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both rs3738401 and rs821616 showed not significantly association with schizophrenia in the Caucasian, Asian, Japanese or Han Chinese populations.
|
29410289 |
2018 |
|
rs3738401
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Both rs3738401 and rs821616 showed not significantly association with schizophrenia in the Caucasian, Asian, Japanese or Han Chinese populations.
|
29410289 |
2018 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analyses results suggested that DISC1 polymorphisms (rs821616 and rs821597) increased SCZ risk in overall populations.
|
29031911 |
2018 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Meta-analyses results suggested that DISC1 polymorphisms (rs821616 and rs821597) increased SCZ risk in overall populations.
|
29031911 |
2018 |
|
rs1000731
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant relationship between other DISC1 polymorphisms (rs3738401, rs2273890, rs3738398, rs3738402, rs2492367, rs843979, rs3737597, rs4658971, rs1538979, rs1000731 and rs3738399) and SCZ.
|
29031911 |
2018 |
|
rs3738399
|
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no significant relationship between other DISC1 polymorphisms (rs3738401, rs2273890, rs3738398, rs3738402, rs2492367, rs843979, rs3737597, rs4658971, rs1538979, rs1000731 and rs3738399) and SCZ.
|
29031911 |
2018 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interaction of DISC1 rs821616 T allele with the NRG1 rs3924999 A allele or that of DISC1 rs821597 A allele with NRG1 rs3924999 A allele had synergic effects on the development of sc</span>hizophrenia.
|
27236031 |
2016 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, in the male subgroup, the DISC1 rs821597 genotype GA or GA/AA exhibited increased risk of s</span>chizophrenia.
|
27236031 |
2016 |
|
rs821616
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our previous study confirmed that the 'AA' genotype carriers of DISC1 single nucleotide polymorphism (SNP) rs821616 had a significantly increased risk for schizophrenia (SCZ) in comparison with noncarriers.
|
26945459 |
2016 |
|
rs821597
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs3737597
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs17817356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs9661837
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs980989
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Polymorphisms in DISC1 gene showed only marginally statistically significant association with schizophrenia (rs17817356) or no association whatsoever (rs821597 and rs980989) while two polymorphisms (rs9661837 and rs3737597) were found to be only slightly polymorphic in the samples.
|
25889058 |
2015 |
|
rs373288445
|
|
|
0.010 |
GeneticVariation |
BEFREE |
D2R-DISC1 complex levels are increased in conjunction with decreased GSK-3α/β (Ser21/9) phosphorylation in both postmortem brain tissue from schizophrenia patients and in Disc1-L100P mutant mice, an animal model with behavioral abnormalities related to schizophrenia.
|
25433637 |
2014 |